MECLOFENAMATE SODIUM
- Product Name
- MECLOFENAMATE SODIUM
- CAS No.
- 6385-02-0
- Chemical Name
- MECLOFENAMATE SODIUM
- Synonyms
- ci583;C02996;Movens;meclomen;Meclonax;Meclofenamate;SODIUM MECLOFENAMATE;sodiummeclophenamate;MECLOFENAMATE SODIUM;MECLOFENAMATESODIUM,USP
- CBNumber
- CB7102365
- Molecular Formula
- C14H10Cl2NO2.Na
- Formula Weight
- 318.13
- MOL File
- 6385-02-0.mol
MECLOFENAMATE SODIUM Property
- Melting point:
- 287-291 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- White solid.
- color
- White to Off-White
- Water Solubility
- Soluble in water at 50mg/ml. Also soluble in DMF, DMSO or ethanol
- Merck
- 14,5779
- Stability:
- Hygroscopic
Safety
- WGK Germany
- 3
- RTECS
- CB2975500
- HS Code
- 2922498050
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M4531
- Product name
- Meclofenamic acid sodium salt
- Packaging
- 1g
- Price
- $56.6
- Updated
- 2024/03/01
- Product number
- 1377803
- Product name
- Meclofenamate Sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $467
- Updated
- 2024/03/01
- Product number
- M1269
- Product name
- Sodium Meclofenamate
- Packaging
- 1G
- Price
- $63
- Updated
- 2024/03/01
- Product number
- M1269
- Product name
- Sodium Meclofenamate Hydrate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 10g
- Price
- $372
- Updated
- 2024/03/01
- Product number
- J60484
- Product name
- Meclofenamic acid sodium salt, 99+%
- Packaging
- 1g
- Price
- $43.65
- Updated
- 2024/03/01
MECLOFENAMATE SODIUM Chemical Properties,Usage,Production
Description
Meclofenamate is a time-
Originator
Meclomen,Warner Lambert,US,1980
Uses
antiinflammatory, antipyretic
Uses
Meclofenamate Sodium is an NSAID used in the treatment of chronic pain.
Indications
Meclofenamate sodium (Meclomen) is prescribed for rheumatoid arthritis and osteoarthritis. The fenamates show no clear superiority in antiinflammatory activity and may produce more adverse effects than other NSAIDs.
Definition
ChEBI: An organic sodium salt derived from meclofenamic acid. Its monohydrate is used for the treatment of dysmenorrhoea (painful periods), osteoarthritis and rheumatoid arthritis.
Manufacturing Process
A mixture consisting of 22.7 g potassium o-bromobenzoate, 16.6 g 2,6- dichloro-3-methylaniline, 12 ml N-ethylmorpholine, 60 ml diethylene glycol dimethyl ether, and 1.0 g anhydrous cupric bromide is heated in a nitrogen atmosphere at 145°C to 155°C for 2 hours. The reaction mixture is diluted with 60 ml diethylene glycol dimethyl ether and acidified with 25 ml concentrated hydrochloric acid. The acidic mixture is diluted with 100 ml of water and the liquid phase decanted from the insoluble oil. The insoluble oil is stirred with methanol and the crystalline N-(2,6-dichloro-3-methylphenyl) anthranilic acid which separates is collected and washed with methanol. The product, after recrystallization from acetone-water mixture, melts at 248°C to 250°C.
brand name
Meclomen (Parke-Davis).
Therapeutic Function
Antiinflammatory
General Description
Meclofenamate sodium (Meclomen) is available for use inthe treatment of acute and chronic RA, OA, and primarydysmenorrhea. It is metabolized in a similar manner tomefenamic acid discussed above, thus a similar restriction isalso applied to meclofenamate. The most significant side effectsare GI, including diarrhea.
Pharmacokinetics
Meclofenamate sodium is rapidly and almost completely absorbed following oral administration, reaching peak plasma
levels within 2 hours. It is highly bound to plasma proteins (99%) and has a plasma half-life of 2 to 4 hours.
Metabolism involves oxidation of the methyl group, aromatic hydroxylation, monodehalogenation, and conjugation.
Urinary excretion accounts for approximately 75% of the administered dose. The major metabolite is the product of
3′-methyl oxidation and has been shown to possess anti-inflammatory activity.
Clinical Use
Meclofenamate sodium is indicated for the relief of mild to moderate pain, the acute and chronic treatment of rheumatoid arthritis and osteoarthritis, the treatment of primary dysmenorrhea, and the treatment of idiopathic, heavy menstrual blood loss.
MECLOFENAMATE SODIUM Preparation Products And Raw materials
Raw materials
Preparation Products
MECLOFENAMATE SODIUM Suppliers
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2127
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- 70
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
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- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6393
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- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
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- Advantage
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- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9926
- Advantage
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View Lastest Price from MECLOFENAMATE SODIUM manufacturers
- Product
- SodiuM MeclofenaMate Monohydrate 6385-02-0
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-29
- Product
- MECLOFENAMATE SODIUM 6385-02-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-15